Photodynamic killing of isolated neuron by hematoporphyrin derivatives photoheme and photosan-3
Anatoly B. Uzdensky1, Andrew F. Mironov2, Gerd Mueller von der Haegen3
1)Rostov State University, Rostov-on-Don, Russia;
Photodynamic therapy (PDT) is a cancer treatment modality based on the local photodamage of malignant tissue after photosensitizer (PS) accumulation ,. The first and favorite PS used successfully in PDT was hematoporphyrin derivative . New PS generations were synthesized recently on the base of this substance. They include Photoheme (Russia) and Photosan (Germany). The composition of these drugs is very complex and includes a mixture of monomers, oligomers , and polymeric forms. It is of interest to compare photodynamic efficiencies of these PS using a simple model object such as a single nerve cell providing continuous monitoring of the cell membrane state and proposed previously for the comparative study of different photosensitizers,.