Frédéric Pierard*, Carole Bresson* and Andrée Kirsch-De Mesmaeker*
* Université Libre de Bruxelles, Chimie Organique Physique, CP 160/08, 50 av. F.D. Roosevelt, B-1050 Bruxelles, Belgium
In this part, the interaction and photoreactions of Ru(II) complexes with DNA are described.
Potential applications of Ru(II) complexes as photoprobes for the genetic material are also shown with emphasis on the possible stereoselective recognition of the chirality of DNA helicoidal structures.
The chiral precursor [Ru(L)2(pyridine)2]2+
to see this compound in a 3D representation and make it rotate or change the representation (CPK, spacefill...), you need the MDL Chemscape ChimeTM (dowload this plug-in at mdl using the previous link), a Netscape Navigator plug-in. Each Chime plug-in is "live"; you can use the right mouse button (click and hold down the mouse button on the Macintosh) to modify properties of the plug-in (try it!).
Conclusions and Perspectives
[Ru(L)2(pyridine)2]2+ are useful chiral building blocks as already demonstrated by von zelewsky and coworkers. The new [Ru(TAP)2(pyridine)2]2+ precursor has however not yet been optically resolved probably because of its high polarity which prevents application of the same methodology as for [Ru(phen)2(pyridine)2]2+.
The authors are grateful to
- Dr. Michel Luhmer and Dr. Kristin Bartik (U.L.B., Belgium) for the 600MHz Nmr spectroscopy.
- Pr. Jerome Lacour (University of Geneva, Switzerland) for the Trisphat experiments.
- Pr Alex von Zelewsky (Fribourg University, Switzerland) for a research stay in his lab.
- F.R.I.A. (Fonds pour la Recherche dans l'Industrie et l'Agriculture) for a fellowship.
- for financial support :
- the E.U. (Training and Mobility of Researchers, T.M.R. program).
- the S.S.T.C. (Service affaires Scientifiques et Culturelles, P.A.I.-I.U.A.P. 4/11 program).