Results and DiscussionFluorescence measurement of PpIX induced by ALA-PEG acid esters
Figure 1
Figure 2 Once inside the cell, ALA esters are rapidly hydrolysed by cellular esterases into free ALA acid which can then enter the metabolic pathway leading to the production of PpIX [4]. As displayed on figures 1 and 2, ALA hexylester resulted in the highest relatives fluorescence values whereas ALA-PEG-esters 4 and 5 are less efficient for the production of PpIX. However, we carried out a premilary study of the ALA-PEG-esters toxicity and first
results demonstrated that these derivatives seem to be less cytotoxic at high
concentrations than corresponding alkyl esters. Fluorescence measurement of PpIX induced by ALA derivatives containing peptide
Figure 3
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