ALA-PEG-esters are promising photosensitizer precursors because of their potential weaker toxicity. Full toxicity study of ALA-PEG-esters in different cell types is in progress.

Optimization of the PEG chain length will moreover define the most promising ALA-PEG-ester derivative for an optimal penetration.

ALA-ester-peptide derivatives are able to release free ALA acid leading to PpIX formation. An enhancement of the selectivity can be expected, targeting specific peptidases.


We thank the Swiss National Science Foundation and Swiss Chemical Industry for generous financial support.

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